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系统性红斑狼疮患者血液中有哪些抗体

2019-2-27 15:29| 发布者: admin| 查看: 3830| 评论: 154

简介:系统性红斑狼疮患者有许多自身抗体,如抗核抗体、抗质抗体、抗红细胞抗体、抗血小板抗体、抗凝血因子抗体、抗其他组织(甲状腺等)抗体。其中,抗核抗体应用最为广泛和最为重要。 (1)抗核抗体:抗核抗体是指抗细胞核内物 ...
    系统性红斑狼疮患者有许多自身抗体,如抗核抗体、抗质抗体、抗红细胞抗体、抗血小板抗体、抗凝血因子抗体、抗其他组织(甲状腺等)抗体。其中,抗核抗体应用最为广泛和最为重要。

    (1)抗核抗体:抗核抗体是指抗细胞核内物质的抗体。95%以上的系统性红斑狼疮患者有抗核抗体。但抗核抗体阳性不一定是红斑狼疮,因为其他自身免疫性结缔组织病也可有抗核抗体,正常老年人、感染或药物因素也可使抗核抗体阳性。高滴度抗核抗体是诊断系统性红斑狼疮的重要血淸学依据,经治疗后抗核抗体仍为阳性,不等于疾病还未控制,即抗核抗体商度不一定与疾病的严重程度相关。抗核抗体中以抗 ds-DNA抗体和抗Sm抗体最为重要。因为抗ds-DNA抗体常常与疾病的活动性相关,绝大部分患者经治疗后,随着病情控制则抗ds-DNA抗体变为阴性。抗Sm抗体通常是诊断红斑狼疮的重要抗体,但它与疾病活动度关系不大。此外,系统性红斑狼疮患者还可有抗SSA抗体、抗SSB抗体、抗RNP抗体等。抗SSA抗体和抗SSB抗体阳性的患者常常有口干、眼干等症状,抗RNP抗体阳性的患者常常有雷诺现象。50%~70%的系统性红斑狼疮患者抗组蛋白抗体阳性。由药物引起的药物性红斑狼疮几乎100%有抗组蛋白抗体。

系统性红斑狼疮患者血液中有哪些抗体13 作者: 来源:


    (2)类风湿因子:20%~30%系统性红斑狼疮患者类风湿因子阳性,所以类风湿因子阳性不一定是类风湿关节炎。

    (3)抗磷脂抗体:抗磷脂抗体的存在可以造成动、静脉栓塞;也可引起血小板减少而出血。抗磷脂抗体除发生脑病外,还可导致死胎或流产。

    (4)其他自身抗体:抗细胞膜抗体、抗淋巴细胞抗体、抗神经元抗体等。

    系统性红斑狼疮有许多自身抗体,有的对疾病诊断有帮助,有的与疾病活动有关,因此,患者应经常做血液检查来监测病情。

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